Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.4, p. 357–364, 2022

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.41, No.4, p. 357–364, 2022

Title: Characterization of inflammatory profiles and endothelial dysfunction in diabetic limb arterial occlusion
Author: Liying Xu, Yudong Fang, Jianfei Yang, Manchen Zhao, Hongtao Xu, Pengchao Xing, Yemin Cao
Abstract:  Our study aims to detect the changes of adiponectin (APN), endothelin 1 (ET)-1, nitric oxide (NO), cystatin C (cysC) in diabetic limb arterial occlusion (DLAO) patients and unravel their associations with endothelial function.
Total 240 type 2 diabetes mellitus (T2DM) patients were divided into a DM group (n = 80, ankle brachial index (ABI) ≥ 0.9) and a DLAO group (n = 160, ABI ses in cysC and ET-1, and significant decreases in APN, NO, FMD and NMD of DLAO patients compared to T2DM patients. Serum APN and NO were positively correlated with ABI, while serum cysC and ET-1 were negatively correlated with ABI. cysC, ET-1 and diastolic blood pressure (DBP) were independent predictors of the severity of DLAO. Serum APN was positively correlated with FMD, NMD and NO, but was negatively correlated with ET-1 and cysC. FMD and NMD were positively correlated with APN and NO, and negatively correlated with ET-1 and cysC. Our study deciphers opposite roles of APN, NO, cysC and ET-1 in the development of DLAO and maintaining endothelial function.
Keywords: Ankle brachial indice — Flow-mediated dilation — Nitroglycerin-mediated dilation — Endothelial function — Inflammation — Diabetes
Published online: 28-Jul-2022
Year: 2022, Volume: 41, Issue: 4 Page From: 357, Page To: 364
doi:10.4149/gpb_20220191


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