Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.4, p. 299–308, 2022

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.41, No.4, p. 299–308, 2022

Title: Effect of epicatechin on inflammatory cytokines and MAPK/NF-κB signaling pathway in lipopolysaccharide-induced acute lung injury of BALB/c mice
Author: Zelin Li, Xiaoping Fu, Yingrun Fan, Chunyan Zhao, Qiuting Wang, Li Feng, Xiaojing Shen, Zhonghui Han, Jiangping Fan
Abstract: This study evaluated the anti-inflammatory effect of epicatechin (EC) on acute lung injury (ALI) induced by lipopolysaccharide (LPS) of tracheal installation in BALB/c mice. It was observed that EC could alleviate not only the histopathological changes but also decrease the wet/dry weight (W/D) ratio of lung tissues. It also suppressed the release of IL-1β, IL-6, and TNF-α in serum, bronchoalveolar lavage fluid (BALF), and lung tissues, respectively. A quantitative real-time PCR-based study further indicated that EC also inhibited the levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA in lung tissues. In addition, the Western blot report suggested that EC was closely involved in the inhibition of phosphorylation of ERK, JNK, p38, p65, and IκB in mitogen-activated protein kinases (MAPK) and nuclear factor-κB (NF-κB) signaling pathway. These results provide an experimental and theoretical basis for treating pulmonary inflammation by EC.
Keywords: Epicatechin — Acute lung injury — Inflammation — Phosphorylation
Published online: 28-Jul-2022
Year: 2022, Volume: 41, Issue: 4 Page From: 299, Page To: 308
doi:10.4149/gpb_2022023


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