Home General Physiology and Biophysics 2022 General Physiology and Biophysics Vol.41, No.4, p. 275–286, 2022

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Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.41, No.4, p. 275–286, 2022

Title: Remote conditioning as protective strategy influencing ubiquitin-mediated stress response in the rabbit spinal cord after ischemia/reperfusion
Author: Marianna Danková, Iveta Domoráková, Zuzana Fagová, Milan Stebnický, Eva Mechírová, Štefan Polák
Abstract: The aim of presented study was to investigate the model of non-invasive method of remote conditioning induced by compression of left forelimb with a tourniquet in three cycles of 2 min of ischemia each followed by 2 min of reperfusion and its influence on the rabbit spinal cord ischemia/reperfusion injury via ubiquitin-mediated stress response.
Ubiquitin immunoreaction in spinal cord motor neurons as well as detection of neuronal survival in ventral horns of spinal cord were evaluated. Significantly increased (p t remote conditioning significantly attenuated degeneration of motor neurons in all conditioned groups versus SC-ischemia groups in each time point. According to our results, we concluded that the remote conditioning induced by transient limb ischemia is relevant stimulus that provides potent neuroprotection in a model of spinal cord ischemia/reperfusion injury.
Keywords: Ischemia/reperfusion injury — Rabbit — Remote conditioning — Spinal cord — Ubiquitin
Published online: 28-Jul-2022
Year: 2022, Volume: 41, Issue: 4 Page From: 275, Page To: 286
doi:10.4149/gpb_2022021


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