Neoplasma Vol.51, p.25-29, 2004
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Title: Serum levels of interleukin-18 and nitrite+nitrate in renal cell
carcinoma patients with different tumor stage and grade
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Author: S., SOZEN
; U., COSKUN
; B., SANCAK
; N., BUKAN
; N., GUNEL
; L., TUNC
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Abstract: Interleukin (IL-18) and nitric oxide (NO) are immunoregulatory
cytokines that have been suggested to participitate in the
multistep process of carcinogenesis. In this study, serum IL-18
and nitrite+nitrate levels (as an index of NO generation) were
measured in 26 patients with histologically confirmed renal cell
carcinoma (RCC) before surgical procedure and in 8 healthy
controls. RCC patients showed significantly higher serum IL-18
levels when compared to the control subjects (p<0.001). Serum IL-
18 levels were found to be similar in patients with T1 and T2, T3,
T4 tumors (p>0.05). Patients with grade 3 and 4 tumors showed
significantly higher serum IL-18 levels when compared to the
patients with grade 1 and 2 tumors (p<0.05). No significant
difference was found in serum nitrite+nitrate levels between RCC
patients and control subjects (p>0.05). Serum nitrite+nitrate
levels were lower in patients with grade 3 and 4 tumors than those
with grade 1 and 2 tumors, but this was not statistically
significant (p=0.063). In conclusion, elevated serum level of IL-
18 in RCC patients than in controls and extra-increase of this
level in those with high grade tumors may reflect the degree of
human defence mechanisms against tumor cells in RCC.
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Keywords: interleukin-18, nitric oxide, renal cell carcinoma, nitrate,
nitrite
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Year: 2004, Volume: 51, Issue: |
Page From: 25, Page To: 29 |
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