Neoplasma Vol.52, p.231-237, 2005
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Title: EGFR LI and Ki-67 LI are independent prognostic parameters
influencing survivals of surgically treated squamous cell lung
cancer patients
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Author: J., NIEMIEC
; L.S., KOLODZIEJSKI
; S., DYCZEK
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Abstract: In literature there are still opinion differences concerning the
prognostic significance of epidermal growth factor receptor
(EGFR) expression and proliferative potential in patients with non
small cell lung cancer (NSCLC). This prompted us to
study those parameters.
The Ki-67 labeling index (Ki-67 LI), EGFR labeling index (EGFR
LI), and mitotic index (MI) were analyzed in the
group of 78 consecutive, surgically treated squamous cell lung
cancer (SqCLC) patients. The expression of Ki-67 and EGFR
protein was visualized on formalin fixed, paraffin embedded
sections using immunohistochemistry (IHC). Mitotic index
was assessed on formalin fixed, paraffin embedded sections,
stained with hematoxylin and eosin using morphological
criteria.
Mean values of Ki-67 LI and MI were higher for G2+G3 tumors than
for G1 tumors. EGFR LI was higher for G1+G2 than
for G3 tumors, and for pT3 than for pT1+pT2 tumors. Patients
having tumors with Ki-67 ˇÜ28% or 13% ˇÝEGFR LI + EGFR
LI 80% survived significantly shorter than those having tumors
with Ki-67 LI >28% or <13% ˇÜGFR LI 80%.
In multivariate analysis, 13% EGFR LI 80% and Ki-67 28% were
independent negative prognostic parameters influencing
survivals of SqCLC patients.
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Keywords: Ki-67 labeling index, EGFR labeling index, mitotic index, squamous
cell lung cancer, prognostic factor
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Year: 2005, Volume: 52, Issue: |
Page From: 231, Page To: 237 |
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