Neoplasma Vol.51, p.456-459, 2004
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Title: Genetic imbalances in benign bone tumors revealed by comparative
genomic hybridization
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Author: T., OZAKI
; D., WAI
; K-L., SCHAEFER
; G., GOSHAGER
; W., BOECKER
; B., DOCKHORN-DWORNICZAK
; Ch., POREMBA
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Abstract: There have been no reports on choromosomal aberrations of benign
bone tumors revealed by comparative genomic hybridization (CGH).
CGH analysis of benign tumors may be useful in understanding the
mechanism of tumorigenesis with comparisons to malignant tumors.
There were 4 tumors (2 enchondromas, one chondromyxoid fibroma,
and one osteoid osteoma) and 8 tumor-like conditions (4 aneurysmal
bone cysts (ABCs), one eosinophilic granuloma, one fibrous
dysplasia, one solitary bone cyst, and one Rosai-Dorfman disease)
available for analysis. One of 2 enchondromas and one of 4 ABCs
exhibited rapid growth. Six lesions showed chromosomal
aberrations, while 6 others did not. The most frequent aberrations
were the loss of a whole chromosome-19 in 6 cases, the loss of
chromosome-arm 22q in 4 cases, and the loss of chromosome-arm 17p
in 3 cases. Gains were seen in 13q21 in 2 cartilaginous tumors and
at 12q15-q21 in eosinophilic granulomas. Therefore, in benign bone
tumors or tumor-like lesions, chromosomal aberrations are not
frequent; however, some clear tendencies of clustering of
aberrations can be observed.
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Keywords: genetic imbalance, genomic hybridization, benign tumors,
chromosomal aberrations
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Year: 2004, Volume: 51, Issue: |
Page From: 456, Page To: 459 |
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