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Neoplasma Vol.62, No.4, p.531-540, 2015 |
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Title: A recombined fusion protein SP5.2/tTF induce thrombosis in tumor blood vessel | ||
Author: S. LV, M. YE, X. WANG, Z. LI, X. CHEN, X. DOU, Y. DAI, F. ZENG, L. LUO, C. WANG, K. LI, X. LUO, J. YAN, X. LI | ||
Abstract: Tumor vascular targeting is one of the most promising strategies in tumor therapy. Here we used E.coli to express a recombinant SP5.2/tTF fusion protein, which, as a tumor vascular targeting agent, consists of SP5.2 (a peptide selectively binding and targeting VEGFR-1 on tumor endothelial cells) and truncated tissue factor (tTF)and aimed to explore its anti-tumor activities. In tumor xenograft studies, SP5.2/tTF selectively targeted the tumor, induced thrombosis, and led to retardation and even regression of tumor growth (growth inhibition ratio = 70%, P< 0.05).
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Keywords: truncated tissue factor, SP5.2, fusion protein, tumor vascular targeting, thrombosis, anti-tumor | ||
Published online: 18-May-2015 | ||
Year: 2015, Volume: 62, Issue: 4 | Page From: 531, Page To: 540 | |
doi:10.4149/neo_2015_064 |
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