Neoplasma Vol.53, p.418-423, 2006
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Title: In vivo fluorescence diagnostics and photodynamic therapy of
gastrointestinal superficial polyps with aminolevulinic acid. A
clinical and spectroscopic study
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Author: J., SMOLKA
; A., MATEASIK
; B., CUNDERLIKOVA
; L., SANISLO
; P., MLKVY
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Abstract: In the present study initial results of clinical study related to
the treatment of patients having different types of precancerous
lesions in the area of esophagus, stomach and intestine by
photodynamic therapy (PDT) based on aminolevulinic acid
(ALA-PDT) are reported. The procedure was performed by laser fibre
system with the light guides introduced through biopsy
channel of an endoscope. In addition, in vivo fluorescent
diagnostics and spectral analyses of biopsies were performed.
Each patient had a positive response to therapy. In two cases
there was a total response and in other five cases more than
sixty percent of suspected area was removed. Additionally,
sigilocellular carcinoma of stomach was revealed in one case. It
appears from the results of this study, that the treatment of
precancerous lesions with ALA-PDT could be successful treatment
modality.
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Keywords: fluorescence diagnostics, photodynamic therapy, protoporphyrin IX
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Year: 2006, Volume: 53, Issue: |
Page From: 418, Page To: 423 |
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