Neoplasma Vol.52, p.364-368, 2005
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Title: A pilot study testing the genetic polymorphism of N-acetyltransferase 2 as a risk factor in lung cancer
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Author: V., HABALOVA
; J., SALAGOVIC
; I., KALINA
; J., STUBNA
; |
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Abstract: NAT2 as phase II enzyme is involved in the detoxification/activation of various drugs, environmental substances and carcinogenic
compounds. A genotyping approach has been used to investigate NAT2 genotype with putative relevance in lung
cancer in population of 110 Slovak-Caucasians patients and 167 non-malignant individuals from the same region. Slow
acetylation was not observed to be a significant risk factor of lung cancer development (OR=1.19; 95% CI: 0.71–1.99).
However, one genotype responsible for slow acetylation (NAT2*5B/*6) was observed significantly more frequently in lung
cancer patients with squamous cell carcinoma compared with control subjects (OR=2.24; 95% CI: 1.14–4.34). Stratified
analysis showed an increasing impact of the specific allelic combination NAT2*5B/*6 in non-smokers (OR=6.5; 95% CI:
1.25–15.08). In the case of squamous lung carcinoma an analysis revealed a tendency to adversely affect cancer risk in the
individuals with the mentioned genotype in younger than 60 years (OR=3.14; 95% CI: 0.98–9.72) non-smokers (OR=10.40;
95% CI: 1.35–118.89) and in females (OR=4.25; 1.08–16.25). Additional studies are needed to confirm the results we observed
and to assess the impact of other effects (specific allelic combinations, sex differences and histological subtype of
lung cancer) on NAT2 susceptibility in lung carcinogenesis.
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Keywords: NAT2, lung cancer, susceptibility, and genetic polymorphism
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Year: 2005, Volume: 52, Issue: |
Page From: 364, Page To: 368 |
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