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Neoplasma Vol.62, No.1, p.34-40, 2015 |
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Title: Knockdown of NF-κB p65 subunit expression suppresses growth of nude mouse lung tumor cell xenografts by activation of Bax apoptotic pathway | ||
Author: Y. QU, X. ZHANG, R. WU | ||
Abstract: Nuclear factor-kappaB (NF-κB) is an important transcriptional factor and regulates a variety of pathophysiologic process involved in cell survival and death. The present study assesses the effects of NF-κB p65 subunit knockdown in suppression of nude mouse lung tumor cell xenografts and understands the underlying molecular events. The TUNEL positive (apoptosis) cells in xenograft sections were 45 ± 5 in PBS and 38 ± 3 in NC siRNA, but increased to 271 ± 11 in p65 siRNA-treated mice. Compared to the PBS or the NC mice, levels of Bax mRNA and protein in tumor xenografts were significantly upregulated in p65 siRNA-treated mice. |
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Keywords: NF-κB, lung cancer, apoptosis, small interfering RNA, xenografts | ||
Published online: 17-Oct-2014 | ||
Year: 2015, Volume: 62, Issue: 1 | Page From: 34, Page To: 40 | |
doi:10.4149/neo_2015_005 |
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