Neoplasma Vol.55, No.1, p.42-46, 2008
|
Title: Preventive effects of letrozole in the model of premenopausal
mammary carcinogenesis |
Author: P. KUBATKA, V. SADLONOVA, K. KAJO, G. NOSALOVA, Z. FETISOVOVA |
|
Abstract: Single – agent therapy with aromatase inhibitors has no established role in premenopausal women with breast cancer. In this study, tumor suppressive effects of letrozole in the prevention of N-methyl-N-nitrosourea – induced mammary carcinogenesis in female Sprague-Dawley rats were evaluated. Letrozole was dietary administered in two concentrations – 1 mg/1 kg (LETRO 1), and 10 mg/1 kg (LETRO 10). Letrozole suppressed incidence of mammary gland cancer by 93 % (Pns were not significantly changed. An increase in body weight gain and food intake was found in the groups LETRO 1 and LETRO 10 compared with the control group (P<0.0001). The present study points to high tumor suppressive effects of letrozole in premenopausal model of mammary carcinogenesis in female rats.
|
|
Keywords: mammary carcinogenesis, rat, chemoprevention, letrozole, aromatase inhibitors. |
Year: 2008, Volume: 55, Issue: 1 |
Page From: 42, Page To: 46 |
|
|
|
|
download file |
|
|
|
|