Neoplasma Vol.52, p.494-496, 2005
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Title: Evaluation of treatment results and toxicity in cases of repeated radiation therapy of spinal metastasis
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Author: K., ROSZKOWSKI
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Abstract: The study evaluates retrospective results and toxicity in repeated
radiation therapy in patients with recurrent pain caused
by backbone metastasis, having undergone previous radiotherapy in
the same body region. Fifty-seven patients were analyzed:
24 women and 33 men, aged 45–74 years (median = 59 years). They
underwent a second radiation therapy treatment
of the spinal column, between March 2002 and May 2004, performed
due to recurrent pain in the previously irradiated region.
The radiation used cobalt isotope 60 (60Co), to include the
metastatically changed vertebrae and the margin of the adjusting
healthy upper and lower vertebra. The radiated skin area measured
84–104 cm2. Patients were divided into 3 groups
depending on their treatment schemas:
12 patients – first course of radiotherapy 4 Gy x 5, second 4 Gy x
5;
16 patients – first course of radiotherapy 4 Gy x 5, second 8 Gy x
1;
29 patients – first course of radiotherapy 8 Gy x 1, second 8 Gy x
1.
The time delay between the first and the second radiation
therapies was between 11 and 766 days (median = 135 days).
An analgesic effect was achieved with most treated patients –
41/57 (71.9%) with the use of second radiotherapy and with
an insignificant percentage of complications, unimportant from the
clinical point of view. No serious complications such as
paralysis, paresis, spinal cord necrosis, neurological dysfunction
of urethral or sigmoidorectal sphincters were noted in any
of the treated patients.
Based on our experience, this retrospective analysis shows
usefulness of the second radiotherapy treatment as a safe
method of palliative treatment in cases of painful bone metastasis
appearing after a previous radiation therapy.
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Keywords: re-irradiation, spinal cord, metastases, toxicity
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Year: 2005, Volume: 52, Issue: |
Page From: 494, Page To: 496 |
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