General Physiology and Biophysics Vol.35, No.1, p.55–62, 2016
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Title: Concept of relative variability of cardiac action potential duration and its test under various experimental conditions |
Author: János Magyar, Kornél Kistamás, Krisztina Váczi, Bence Hegyi, Balázs Horváth, Tamás Bányász, Péter P. Nánási, Norbert Szentandrássy |
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Abstract: Beat-to-beat variability of action potential duration (short-term variability, SV) is an intrinsic property of mammalian myocardium. Since the majority of agents and interventions affecting SV may modify also action potential duration (APD), we propose here the concept of relative SV (RSV), where changes in SV are normalized to changes in APD and these data are compared to the control SV-APD relationship obtained by lengthening or shortening of action potentials by inward and outward current injections. Based on this concept the influence of the several experimental conditions like stimulation frequency, temperature, pH, redox-state and osmolarity were examined on RSV in canine ventricular myocytes using sharp microelectrodes. RSV was increased by high stimulation frequency (cycle lengths
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Keywords: Short-term variability — Action potential duration — Cardiac ion currents — Canine myocytes |
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Published online: 15-Dec-2015
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Year: 2016, Volume: 35, Issue: 1 |
Page From: 55, Page To: 62 |
doi:10.4149/gpb_2015019
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