General Physiology and Biophysics Vol.43, No.1, p 25–36, 2024
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Title: Effect of quercetin administration during the first two weeks post-weaning on the development of non-alcoholic fatty liver disease and dyslipidaemia in Sprague Dawley rats fed a high fructose diet |
Author: Ramatsobane Tladi, Kennedy H. Erlwanger, Janine Donaldson |
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Abstract: Hepatic steatosis and dyslipidaemia are associated with excessive fructose consumption. We investigated the effect of quercetin intake during the early pre-weaning period on metabolic dysfunction caused by a high fructose diet. Sprague Dawley rats, 21-day-old, were weaned onto standard rat chow and randomly allocated to four groups which either water or 20% fructose solution to drink with or without quercetin (100 mg/kg body mass). Quercetin was administered for two weeks. Thereafter, rats continued on their respective diets for six weeks without quercetin. Terminally, serum triglyceride concentrations were not significantly different (p > 0.05) between males across groups. However, females receiving quercetin alone had lower serum triglyceride levels than those receiving fructose (p
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Keywords: Post-weaning — Dyslipidaemia — High-fructose diet — Phytochemicals |
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Published online: 17-Jan-2024
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Year: 2024, Volume: 43, Issue: 1 |
Page From: 25, Page To: 36 |
doi:10.4149/gpb_2023033
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