Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
General Physiology and Biophysics Vol.40, No.4, p.257–274 |
||
Title: Identification of an autophagy-related 10-lncRNA-mRNA signature for distinguishing glioblastoma multiforme from lower‑grade glioma and prognosis prediction | ||
Author: Bo Wei, Le Wang, Jingwei Zhao | ||
Abstract: Autophagy may provide the source of nutrients for tumor cells. We aim to develop an autophagy-related signature to predict the progression from lower-grade gliomas (LGG) to glioblastoma multiforme (GBM) and prognosis. Totally, 686 differentially expressed genes (DEGs) and 73 long non-coding RNAs (DELs) were identified between GBM and LGG samples from the Chinese Glioma Genome Atlas (CGGA). Of them, 131 DEGs were intersected with autophagy genes from the Human Autophagy Database; while 54 DELs co-expressed with autophagy-related DEGs. Ten autophagy-related genes were associated with overall survival and could distinguish GBM from LGG, with the accuracy of 0.891 using CGGA dataset and 0.790 using The Cancer Genome Atlas (TCGA) dataset. The risk score was established based on these 10 genes. Patients with higher risk score were at an increased risk of developing GBM (49.7% vs. 21.3%; p |
||
Keywords: Glioblastoma — Lower-grade glioma — Nomogram — Prognostic signature — Autophagy-related genes — Autophagy-related lncRNAs | ||
Published online: 01-Aug-2021 | ||
Year: 2021, Volume: 40, Issue: 4 | Page From: 257, Page To: 274 | |
doi:10.4149/gpb_2021008 |
||
|
![]() |
|