General Physiology and Biophysics Vol.38, No.6, p.545–556, 2019
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Title: Effects of nicorandil on vascular and renal dysfunctions in adenine-induced nephropathy: Possible underlying mechanisms |
Author: Abdelaziz M. Hussein, Mohamed Eldosoky, Hala Abdel Malek, Mohamed Elshafey, Eman El Nashar, Gamal Dahab |
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Abstract: Vascular dysfunctions in chronic kidney disease (CKD) include endothelial dysfunctions and vascular calcification (VC). In the present study, we examined the possible protective effect of nicorandil (potassium channel opener) on renal and vascular dysfunctions in a rat model of adenine-induced nephropathy and its underlying mechanisms. Thirty-four male Sprague-Dawley rats were randomly allocated into 3 groups: Control group, Adenine group (animals received high-adenine diet for 4 weeks), and Nicorandil group (animals received adenine for 4 weeks and nicorandil 1 mg/kg per oral for 4 weeks). The results showed significant reduction in the body weight, heart rate (HR), hemoglobin contents, serum Ca2+ and reduction in the expression of mRNA of endothelial nitric oxide synthase (eNOS) and nuclear factor erythroid related factor 2 (nrf2) genes in aortic tissues with significant increase in arterial blood pressure (ABP), serum creatinine, blood urea nitrogen (BUN), plasma renin activity (PRA), K+ and phosphate (PO43-), urinary albumin excretion (UAE) and aortic VC in Adenine group compared to normal group (p
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Keywords: Nicorandil, Adenine, Vascular calcifications, Kidney, eNOS, Nrf2 |
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Published online: 27-Nov-2019
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Year: 2019, Volume: 38, Issue: 6 |
Page From: 545, Page To: 566 |
doi:10.4149/gpb_2019034
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