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Bratislava Medical Journal Vol.117, No.9, p.539-542, 2016 |
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Title: Dexmedetomidine protected COPD-induced lung injury by regulating miRNA-146a | ||
Author: N. Li, B. S. Ouyang, L. Liu, C. S. Lin, D. D. Xing, J. Liu | ||
Abstract: OBJECTIVE: To study the mechanism of protection provided by dexmedetomidine against COPD-induced lung injury. Cell apoptosis was significantly different in blank and drug groups (21.65±0.86 vs 10.74±0.15; p < 0.05, respectively). The gene expressions of miRNA-146a, p53 and Bcl-2 were significantly downregulated compared with blank group. |
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Keywords: miRNA-146a expression, COPD, IL-1β, TNF-α | ||
Published online: 21-Sep-2016 | ||
Year: 2016, Volume: 117, Issue: 9 | Page From: 539, Page To: 542 | |
doi:10.4149/BLL_2016_106 |
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