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FOR AUTHORS Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.7, p.423–428, 2024
FOR AUTHORS Bratislava Medical Journal 2024 Bratislava Medical Journal Vol.125, No.7, p.423–428, 2024
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Bratislava Medical Journal Vol.125, No.7, p.423–428, 2024 |
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| Title: Invasive and metastatic hydatidiform moles in Slovakia in 1993‒2022 | ||
| Author: Liam MCCULLOUGH, Ludovit DANIHEL, Jozef SUFLIARSKY, Michaela KUBICKOVA, Zuzana NIZNANSKA, Adam ADAMEC, Miroslav KORBEL | ||
| Abstract: OBJECTIVE: A retrospective analysis of invasive and metastatic hydatidiform moles (HM) in the Slovak Republic (SR)‒epidemiology, patient characteristics and treatment outcomes. BACKROUND: Invasive and metastatic mole is a highly curable type of gestational trophoblastic neoplasia. Both invasive and metastatic HM may be cured by hysterectomy without adjuvant chemotherapy. METHODS: Nineteen cases of histopathologically confirmed HM (10 invasive and 9 metastatic) were treated in SR from 1993 to 2022. Patients were divided into two groups according to treatment modality (hysterectomy only ‒ 8; hysterectomy and chemotherapy ‒ 11). The parameters included in the analysis were patient age, antecedent pregnancy, human chorionic gonadotropin level, tumor size and time to remission. RESULTS: The incidence of invasive and metastatic HM in the SR was 1:121,253 pregnancies, or 1:86,589 live births. The overall cure rate was 100%, without recurrence. Hysterectomy was performed as first-line therapy in 14 patients, with a cure rate of 57.1%. 4 out of 8 patients (50%) with metastatic moles, who underwent first-line hysterectomy, were cured without chemotherapy. There was no statistically significant difference between the two groups in all selected parameters. CONCLUSION: First-line hysterectomy may lead to remission without adjuvant chemotherapy or reduce the number of chemotherapies in invasive and metastatic HM (Tab. 4, Fig. 2, Ref. 21). |
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| Keywords: gestational trophoblastic disease, invasive and metastatic mole, hysterectomy, chemotherapy | ||
| Published online: 21-May-2024 | ||
| Year: 2024, Volume: 125, Issue: 7 | Page From: 423, Page To: 428 | |
| doi:10.4149/BLL_2024_65 |
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