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Bratislava Medical Journal Vol.117, No.12, p.730-733, 2016 |
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Title: Is levetiracetam neuroprotective in neonatal rats with hypoxic ischemic brain injury? | ||
Author: Y. Celik, B. Resitoglu, M. Komur, A. Polat, A. E. Arslankoylu, C. Okuyaz, S. Erdogan, H. Beydagi | ||
Abstract: BACKGROUND: The aim of this study was to determine if levetiracetam (LEV) is neuroprotective in neonatal rats with hypoxic-ischemic brain injury (HIBI). In addition, the number of apoptotic neurons in the right hemispheres was significantly lower in the LEV800 group than in the LEV400 group (p = 0.001). Platform finding time (PFT) during MWM testing was significantly shorter in the sham and LEV800 groups on d 4 than on d 1 (p = 0.001 and p = 0.006, respectively); however, PFT did not significantly change between d 1 and d 4 in the control or LEV400 groups (p = 0.91 and p = 0.096, respectively). |
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Keywords: hypoxic ischemic encephalopathy, levetiracetam, new-born. | ||
Published online: 28-Dec-2016 | ||
Year: 2016, Volume: 117, Issue: 12 | Page From: 730, Page To: 733 | |
doi:10.4149/BLL_2016_140 |
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