Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Endocrine Regulations Vol.42, p.23-28, 2008 |
||
Title: HORMONE RESPONSE TO STRESS IN RAT STRAINS OF DIFFERENT SUSCEPTIBILITY TO IMMUNOLOGIC CHALLENGE | ||
Author: L. MACHO, J. ROVENSKY, R. KVETNANSKY, Z. RADIKOVA, M. FICKOVA, S. ZORAD | ||
Abstract: Objective. The aim of this study was to compare the changes in plasma levels of hormones involved in modulation of the immune system function after exposure to stress in two rat strains with different susceptibility to immunoantigens. Methods. Adult rat males of Lewis (LEW) and Fischer 344 (FIS) strains were exposed to restrain stress for 2 hours and blood samples were collected during stress exposure. Other groups of animals were exposed to restrain stress for 2 hours and sacrificed 3 hours later for blood and organ collection. Corticosterone, testosterone, dehydroepiandrosterone, 17ß–estradiol and progesterone were estimated by radioimmunoassay, epinephrine and norepinephrine levels were determined by radioenzymatic method. Results. The levels of plasma corticosterone and catecholamines were significantly higher during stress exposure in FIS as compared to LEW rats. Greater decrease of testosterone levels and higher levels of estradiol were noted after exposure to stress in LEW rats. Higher values of progesterone plasma levels were noted in FIS rats after stress. Conclusions. These results demonstrated the differences in the response of catecholamines, adrenal and gonadal steroids after exposure to stress in LEW and FIS rats with lower levels of hormones with anti-inflammatory action in LEW rats. |
||
Keywords: hormone levels, stress, rat strains | ||
Year: 2008, Volume: 42, Issue: 1 | Page From: 23, Page To: 28 | |
|
download file |
|