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Acta Virologica Vol.58, No.3 p.278-281, 2014 |
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Title: Significance of mutations in hepatitis B virus X gene for the pathogenesis of HB-associated glomerulonephritis | ||
Author: D. HUI, X. YAN, J. WEI, M. RUIXIA, G. GUANGJU | ||
Abstract: In this study, the significance of hepatitis B virus (HBV) X gene mutations for the pathogenesis of HBV-associated glomerulonephritis (HBV-GN) was investigated. DNA was extracted from 50 HBV-GN patients and 60 asymptomatic HBV carriers and subjected to PCR amplification and sequencing of HBV X gene. In HBV-GN patients, missense nucleotide mutations of C1653T, A1726C, A1727T, C1730G, T1753C, A1762T, and G1764A were detected in 84% of subjects, all located in the trans-acting regulatory region of the X gene. In control patients, missense nucleotide mutations of A1632C and A1635C were detected in 8% of subjects, both located in the non-functional region of the X gene. We conclude that, in most HBV-GN patients, X gene missense mutations occurred at some key sites playing an important role in the pathogenesis of HBV-GN. |
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Keywords: hepatitis B virus; glomerulonephritis; X gene; mutation | ||
Year: 2014, Volume: 58, Issue: 3 | Page From: 278, Page To: 281 | |
doi:10.4149/av_2014_03_278 |
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