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Neoplasma Vol.59, No.3, p.264-269, 2012 |
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Title: Kinetics of bilirubin and liver enzymes is useful for predicting of liver graft-versus-host disease | ||
Author: M. KREJCI, J. KAMELANDER, Z. POSPISIL, J. MAYER | ||
Abstract: Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic cell transplantation. We analyzed the kinetics of bilirubin and liver enzymes in 47 cases with liver GVHD and in 47 cases without GVHD after allogeneic transplantation for various hematological malignancies.
The imminent LGVHD episode was defined as the interval from the start of continuous increase (≥ 3 consecutive rising values) of bilirubin and liver enzymes above UNL to the point of LGVHD diagnosis.
The asymptomatic continuous increase in bilirubin, ALT, and GGTP occurred at a median of 5, 12, and 9 days before liver GVHD episode, respectively. |
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Keywords: liver GVHD, kinetics, bilirubin, liver enzymes | ||
Published online: 01-Feb-2012 | ||
Year: 2012, Volume: 59, Issue: 3 | Page From: 264, Page To: 269 | |
doi:10.4149/neo_2012_034 |
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