Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Endocrine Regulations Vol.45, No.3, p.157-161, 2011 |
||
Title: Central hypothyroidism in patients with chronic hepatitis C and relation with interferon-alpha treatment | ||
Author: D. E. Zantut-Wittmann, M. H. Pavan, E. J. Pavin, F.L. Goncales Jr. | ||
Abstract: Objective. Since some authors referred to panhypopituitarism or central hypothyroidism during the treatment of chronic hepatitis C virus (HCV) infection using interferon-α, it is intended to evaluate the prevalence of central hypothyroidism (CH) in HCV patients before and during interferon-α therapy. Patients and Methods. We evaluated 308 HCV patients treated with standard interferon-α (IFN) and/or pegylated-interferon-α (PEG-IFN) associated with ribavirin. Free thyroxine (FT4) and thyrotropin (TSH) levels were measured before, during and after treatment. CH was diagnosed when the level of FT4 was lower than normal values with concomitant normal or lower TSH as verified at least in two consecutive measures. Results. Before treatment, 18 (5.8 %) patients presented CH Twelve patients maintained laboratory changes during the treatment and 17 new patients developed central hypothyroidism. Among the 29 patients (9.4 %) with CH, 11 used IFN, six used PEG-IFN and 12 patients used two or more therapeutic schedules. The differences in gender, age, cirrhosis, viral genotype, duration of treatment and the type of interferon used were not statistically significant. The absence of sustained virologic response was associated with central hypothyroidism (OR=3.83). Conclusion. HCV patients may develop CH due to viral infection or during the interferon treatment. These patients presented 3.83 times more chance of not obtaining sustained virologic response. |
||
Keywords: central hypothyroidism, hepatits C, interferon-alpha | ||
Year: 2011, Volume: 45, Issue: 3 | Page From: 157, Page To: 161 | |
doi:10.4149/endo_2011_03_157 |
||
|
![]() |
|