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Neoplasma Vol.62, No.4, p.627-634, 2015 |
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Title: Prognostic value of interim and restaging PET/CT in Hodgkin lymphoma. Results of the CHEAP (Chemotherapy Effectiveness Assessment by PET/CT) study – long term observation | ||
Author: Z. MILTENYI, S. BARNA, I. GARAI, Z. SIMON, A. JONA, F. MAGYARI, M. GERGELY, Z. NAGY, K. KERESZTES, P. PETTENDI, A. ILLES | ||
Abstract: Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who received standard first-line treatment based on the stage of disease and risk factors. We investigated the differences between the relapse and non-relapse groups based on the clinical pathological characteristics of patients who had positive interim PET/CT results. The five-year overall survival rates were 93.4% in the interim PET negative group and 58% in the interim PET positive group (p<0.001). The five-year relapse-free survival rates for the negative and positive groups were 92.7% and 40.8%, respectively (p<0.001). The negative predictive value was 100% in the early stage group and 82.35% in the advanced stage group. By comparison, the positive predictive values were 53.8% and 58.8%, respectively, in these two groups. In the interim PET positive group, patients over 40 years of age had a significantly higher probability of relapse (p=0.057).
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Keywords: predictive value, Hodgkin lymphoma, PET/CT | ||
Published online: 18-May-2015 | ||
Year: 2015, Volume: 62, Issue: 4 | Page From: 627, Page To: 634 | |
doi:10.4149/neo_2015_075 |
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