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General Physiology and Biophysics Vol.33, No.1, p.13–28, 2014 |
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Title: Quantitative estimation of transmembrane ion transport in rat renal collecting duct principal cells | ||
Author: Alexander V. Ilyaskin, Denis I. Karpov, Dmitriy A. Medvedev, Alexander P. Ershov, Galina S. Baturina, Liubov E. Katkova, Evgeniy I. Solenov | ||
Abstract: Kidney collecting duct principal cells play a key role in regulated tubular reabsorption of water and sodium and secretion of potassium. The importance of this function for the maintenance of the osmotic homeostasis of the whole organism motivates extensive study of the ion transport properties of collecting duct principal cells. The sodium and chloride concentrations ([Na+]in = 37.3 ± 3.3 mM), [Cl-]in = 32.2 ± 4.0 mM) in OMCD cells were quantitatively estimated. Correspondence between the experimentally measured cell physiological characteristics and the values of model permeability parameters was established. Plasma membrane permeabilities and the rates of transmembrane fluxes for sodium, potassium and chloride ions were estimated on the basis of ion substitution experiments and model predictions. In particular, calculated sodium (PNa), potassium (PK) and chloride (PCl) permeabilities were equal to 3.2×10-6 cm/s, 1.0×10-5 cm/s and 3.0×10-6 cm/s, respectively.
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Keywords: renal collecting duct principal cell, membrane transport, ion permeability, pump-leak model | ||
Published online: 26-Aug-2013 | ||
Year: 2014, Volume: 33, Issue: 1 | Page From: 13, Page To: 28 | |
doi:10.4149/gpb_2013063 |
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