General Physiology and Biophysics Vol.31, No.1, p.101

General Physiology and Biophysics Vol.31, No.1, p.101–112, 2012

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
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General Physiology and Biophysics Vol.31, No.1, p.101–112, 2012
Title: Proton magnetic resonance spectroscopy and its diagnostically important metabolites in the brain
Author: Michal Bittšanský, Desanka Výbohová, Dušan Dobrota

Abstract: This review provides a brief summary of the basic principles of proton magnetic resonance spectroscopy (1H MRS) and its application in the human brain. We discuss the chemical structure, signal properties, biological function, normal spatial distribution and diagnostic potential of the most significant metabolites detectable in brain tissue: N-acetylaspartate, N-acetylaspartylglutamate, choline-containing substances, creatine, phosphocreatine, myo-inositol, glutamine and glutamate. We also present a few notes on the importance of proper spectral quantification and contemporary trends in 1H MRS are presented.

Keywords: Brain metabolites – Magnetic resonance spectroscopy

Year: 2012, Volume: 31, Issue: 1	Page From: 101, Page To: 112
doi:10.4149/gpb_2012_007
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