Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Neoplasma Vol.58, No.2, p.104-109, 2011 |
||
Title: Prohibitin as a novel target protein of luteinizing hormone in ovarian epithelial carcinogenesis | ||
Author: L. JIA, X. F. YI, Z. B. ZHANG, Z. P. ZHUANG, J. LI, S. K. CHAMBERS, B. H. KONG, W. ZHENG | ||
Abstract: The exact role of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in ovarian epithelial carcinoma (OEC) development has not been yet characterized. This prompted us to identify particular proteins to better understand the underlying mechanism. Total proteins from ovarian epithelial tumor (OET) cells treated with gonadotropins were analyzed by proteomics. Western blot and immunohistochemistry were used to validate the target protein (prohibitin) and to detect its expression in human ovarian tissue of serous tumors. As the results, prohibitin was found to be significantly up-regulated by LH, with a maximum of 2.5-fold increase at the concentration of 200 mIU/mL. The expression of prohibitin was steadily decreased from benign serous cystadenomas to borderline tumors and serous carcinomas (P < 0.0001). The difference between any two groups was significant (P < 0.001). Collectively, data from this study indicate that prohibitin is one LH-associated protein and it may be protective of ovarian cancer development and progression, supporting that LH may play an inhibitory role in ovarian tumorigenesis. |
||
Keywords: Gonadotropin; Luteinizing hormone; Prohibitin; Ovarian cancer | ||
Year: 2011, Volume: 58, Issue: 2 | Page From: 104, Page To: 109 | |
doi:10.4149/neo_2011_02_104 |
||
|
download file |
|