Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.53, p.434-439, 2006 |
||
Title: Carboxymethyl chitin-glucan enriched diet exhibits protective effects against oxidative DNA damage induced in freshly isolated rat cells | ||
Author: M., LAZAROVA ; J., LABAJ ; G., KOGAN ; D., SLAMENOVA ; | ||
Abstract: The connection between dietary intake of carboxymethyl chitin-
glucan (CM-CG, approximately 200 mg/kg body
weight, during 21 days) and the response of freshly isolated rat
cells to genotoxic treatment with a combination of
photosensitizer Methylene Blue and visible light (MB+VL) was
evaluated in presented study. Blood lymphocytes, testicular
cells, and hepatocytes were isolated from rats fed by a standard
or CM-CG enriched diet and in ex vivo conditions challenged
with oxidative agent. Induced DNA damage was assessed using a
modified comet assay.
When added to the diet, CM-CG itself did not induce any negative
effect on the health condition of animals or on level of
DNA breaks in rat cells. Moreover, the cells isolated from CM-CG
fed animals were more resistant to oxidative stress induced
by visible light-excited Methylene Blue.
In conclusion, we have demonstrated that carboxymethyl chitin-
glucan represents a natural fungal polysaccharide that is
able to exert antimutagenic properties upon application in diet.
|
||
Keywords: photosensitization, oxidative DNA lesions, carboxymethyl chitin- glucan, diet, comet assay | ||
Year: 2006, Volume: 53, Issue: | Page From: 434, Page To: 439 | |
|
download file |
|