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Bratislava Medical Journal Vol.124, No.1, p.59–63, 2023 |
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Title: The effect of the change in hemoglobin-albumin-lymphocyte-platelet scores occurring with neoadjuvant chemotherapy on clinical and pathological responses in breast cancer | ||
Author: Elif YUCE, Serdar KARAKULLUKCU, Hatice BULBUL, Celal ALANDAG, Ismail SAYGIN, Halil KAVGACI | ||
Abstract: INTRODUCTION: Breast-cancer is a common-cause of death in women.(1) We investigated the effects of before/after-NACT on hemoglobin-albumin-lymphocyte-platelet (HALP) scores and of changes therein on clinical/pathological-responses. Pathological-complete-response (pCR) was observed in 24 patients (18.9 %). ORR was higher in Ki-67 > 20 % compared to ≤ 10 % and 10–20 % (90.3 % vs 59.0 % / 78.3 %, respectively, p: 0.027), but no difference occurred in pCR. Neutrophil-lymphocyte-ratio (NLR), platelet-lymphocyte-ratio (PLR), prognostic-nutritional-index (PNI), and HALP were measured before/after NACT. Associations with ORR and pCR were investigated via changes in these with NACT (excepting-PNI), but no-significant results emerged.
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Keywords: breast cancer, objective response rate (ORR), pathological complete response (pCR), hemoglobin-albumin-lymphocyte-platelet (HALP) score. | ||
Published online: 15-Dec-2022 | ||
Year: 2023, Volume: 124, Issue: 1 | Page From: 59, Page To: 63 | |
doi:10.4149/BLL_2023_009 |
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