Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.65, No.2, p.115-126, 2021 |
||
Title: Severe acute respiratory syndrome coronavirus 2 invasion in the central nervous system: a host-virus deadlock | ||
Author: Prodip Kumar Baral, Mohammed Nuruzzaman, Mohammad Sarowar Uddin, Mahmuda Ferdous, Imtiaj Hossain Chowdhury, Shanita Zaman Smrity | ||
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) devastation on the central nervous system (CNS) is ascertained by the present clinical findings and the noticeable signs and symptoms. The CNS involvement of the virus is not trivial; although the brain has highly protective systems, the virus has ways to breach them with a destructive potential. For successful entry of the virus, different possible routes with favorable mechanisms are used. The SARS-CoV-2 invasion induces a mechanism of both the innate and adaptive immune response to control virus replication and removal from the CNS tissues. The cytokine storm and autoimmune response during the immunological events result in demyelination, damage of resident cells and neurons, cerebrovascular thrombosis, and dysregulation of neuro signaling pathways. Furthermore, hypoxia and toxemia accelerate the neurological destruction process. The acute attributions on psychology due to inflammation is a hallmark of CNS involved pathogenesis; nevertheless, the productivity, durability, and longevity of virus-specific lymphocytes are the vital indicators for complete removal of viral antigen and in combat against reinfection of the CNS. |
||
Keywords: CNS invasion; immune response; cytokine storm; demyelination; mental status | ||
Published online: 15-Jan-2021 | ||
Year: 2021, Volume: 65, Issue: 2 | Page From: 115, Page To: 126 | |
doi:10.4149/av_2021_201 |
||
|
download file |
|