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Acta Virologica Vol.61, No.3, p.280-288, 2017 |
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Title: Large protein as a potential target for use in rabies diagnostics | ||
Author: I. S. SANTOS KATZ, M. H. DIAS, I. F. LIMA, L. B. CHAVES, O. G. RIBEIRO, K. C. SCHEFFER, L. K. IWAI | ||
Abstract: Rabies is a zoonotic viral disease that remains a serious threat to public health worldwide. The rabies lyssavirus (RABV) genome encodes five structural proteins, multifunctional and significant for pathogenicity. The large protein (L) presents well-conserved genomic regions, which may be a good alternative to generate informative datasets for development of new methods for rabies diagnosis. This paper describes the development of a technique for the identification of L protein in several RABV strains from different hosts, demonstrating that MS-based proteomics is a potential method for antigen identification and a good alternative for rabies diagnosis. |
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Keywords: rabies virus; large protein; street virus; target; mass spectrometry; proteomics | ||
Published online: 28-Aug-2017 | ||
Year: 2017, Volume: 61, Issue: 3 | Page From: 280, Page To: 288 | |
doi:10.4149/av_2017_306 |
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