Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.57, No.3, p.191-197, 2010 |
||
Title: Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: a study on tissue microarrays | ||
Author: J. Bi, A. L. Guo, Y. R. Lai, B. Li, J. M. Zhong, H. Q. Wu, Z. Xie, Y. L. He, Z. L. Lv, S. H. Lau, Q. Wang, X. H. Huang, L. J. Zhang, J. M. Wen, X. Y. Guan | ||
Abstract: Clusterin (CLU) is expressed in a wide variety of human tissues and fluids. Overexpression of cytoplasmic clusterin (sCLU) has been implicated in cancer development and progression. The aim of the present study is to evaluate the association of sCLU overexpression with clinicopathological features of human gastric carcinomas (GC).We constructed a gastric cancer tissue microarray containing 173 primary gastric carcinomas and 70 paired non-neoplastic mucosa specimens. The expression of sCLU was studied by immunohistochemistry. The correlations between sCLU expression and clinicopathological features, p53 abnormality, as well as Ki67 activation were analyzed. Overexpressions of sCLU was detected in 28.5% (n=165) of primary GCs by immunohistochemical staining, but not in non-neoplastic mucosa. Clinical association study found that overexpression of sCLU was significantly correlated with lymph-node metastasis (p |
||
Keywords: Clusterin; gastric carcinoma; tissue microarray | ||
Year: 2010, Volume: 57, Issue: 3 | Page From: 191, Page To: 197 | |
doi:10.4149/neo_2010_03_191 |
||
|
download file |
|