Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.60, No.2, p.211-213, 2016 |
||
Title: Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells | ||
Author: T. OHSUGI, M. WAKAMIYA, S. MORIKAWA, M. FUJITA | ||
Abstract: Human T-cell leukemia virus type 1 (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATLL). The Tax protein encoded by the pX region of the HTLV-1 genome appears to be a key element in the early stage of ATLL development. In this study, we examined the expression of the downstream of tyrosine kinase (DOK) family members DOK1, DOK2 and DOK3, recently reported to be tumor suppressors, in HTLV-1-transformed T cells (MT-2 and HUT-102) and TL-Om1 cells derived from ATLL leukemic cells. DOK2 and DOK3 expression was significantly reduced in MT-2, HUT-102, and TL-Om1 cells compared with their expression in uninfected T cells, and the expression of DOK3 was reduced by the induction of Tax expression in T cells. |
||
Keywords: adult T-cell leukemia/lymphoma; downstream of tyrosine kinase 1; DOK1; DOK2; DOK3; human T-cell leukemia virus type; tax | ||
Published online: 06-Jun-2016 | ||
Year: 2016, Volume: 60, Issue: 2 | Page From: 211, Page To: 213 | |
doi:10.4149/av_2016_02_211 |
||
|
download file |
|