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Bratislava Medical Journal Vol.119, No.1, p.17-21, 2018 |
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Title: MicroRNA-375 regulates proliferation and apoptosis of glioma cancer cells by inhibiting CTGF-EGFR signaling pathway | ||
Author: L. X. Zhang, W. Jin, J. Zheng, Y. X. Dai, Y. Song, H. B. Ni, J. Jiang, W. B. Liang | ||
Abstract: AIM: To evaluate the correlation between miRNA-375 and cell proliferation and apoptosis in glioma cancer cell. In the cell experiments, the cell proliferation of miRNA group was significantly decreased compared with that of NC group (p < 0.05); the cell apoptosis and G1 phase rate of miRNA group was significantly decreased compared with NC group (p < 0.05, respectively). Depending on the WB assay, the CTGF, EGFR, AKT, Erk and P21 proteins expressions of miRNA group were significantly different compared with proteins expressions of NC group (p < 0.05, respectively). |
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Keywords: miRNA-375, CTGF, EGFR, glioma cancer | ||
Published online: 22-Jan-2018 | ||
Year: 2018, Volume: 119, Issue: 1 | Page From: 17, Page To: 21 | |
doi:10.4149/BLL_2018_004 |
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