Journal info
|
||||
Select Journal
Journals
Bratislava Medical Journal 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Bratislava Medical Journal Vol.119, No.1, p.6-11, 2018 |
||
Title: Decline in peripheral blood NKG2D+CD3+CD56+ NKT cells in metastatic colorectal cancer patients | ||
Author: M. Gharagozloo, A. Rezaei, H. Kalantari, A. Bahador, N. Hassannejad, M. Maracy, N. Nouri, M. Sedghi, H. Ghazanfari, B. Bayat | ||
Abstract: OBJECTIVE: Colorectal cancer (CRC) is one of the main causes of cancer deaths in the world. This cancer can be divided into non-metastatic and metastatic CRC stages. CD3+CD56+ NKT cell subsets are a minor T cell subset in peripheral blood and conduct the killing of tumor cells in direct manner. Little is obvious about levels and surface markers of these cells such as NKG2D in different cancers, especially in CRC. CONCLUSION: The fact that frequency of NKG2D+CD56+ NKT cells was significantly lower in patients with metastatic colorectal cancer compared to healthy controls strengthens the hypothesis that NKT cells can play a substantial role in the protection against human colorectal cancer, and this opens up avenues for novel studies about elucidating the other aspects of tumor surveillance in CRC progression and immunotherapy (Tab. 2, Fig. 2, Ref. 46). |
||
Keywords: low-grade non-metastatic colorectal cancer, high-grade non-metastatic colorectal cancer, metastatic colorectal cancer, CD3+CD56+ NKT cells, NKG2D | ||
Published online: 22-Jan-2018 | ||
Year: 2018, Volume: 119, Issue: 1 | Page From: 6, Page To: 11 | |
doi:10.4149/BLL_2018_002 |
||
|
download file |
|