General Physiology and Biophysics Vol.35, No.1, p.35–43, 2016
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Title: The effect of aerobic exercise on hepatotoxicity induced by intratracheal instillation of iron oxide nanoparticles in Wistar rats |
Author: Azadeh Vasili, Gholamreza Sharifi, Mohammad Faramarzi, Ali Noori,Shora Yazdanshenas |
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Abstract: Iron oxide nanoparticles (IONPS) can cause significant health problems due to their unique physicochemical properties and environmental characteristics. They are found as ultrafine particles in ambient air. After inhalation, these particles move from the lung to phagocytosis tissues, especially the liver. The aim of present study was to investigate the effect of concurrent aerobic exercise and IONPS on liver enzymes and histological hepatic appearance. 48 rats were divided into six groups: experimental 1 (aerobic exercise), experimental 2 (nanoparticle, anesthesia), experimental 3 (aerobic exercise, nanoparticles, anesthesia), placebo 4 (distilled water, anesthesia), placebo 5 (aerobic exercise, anesthesia), and control group. In groups 2 and 3, 40 mg/kg/b.w. of IONPS was injected via intratracheal installation every other day for 14 days. Groups 1, 3, and 4 run on treadmill for 30 minutes with the intensity of 35–40% VO2max (maximal oxygen consumption) every day. ALT was increased in group 1 but decreased in groups 2 and 3. AST was not significant in any of the groups, while ALP was reduced significantly in groups 2 and 3 (p
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Keywords: Aerobic exercise — Iron oxide nanoparticles — Hepatotoxicity — Liver enzyme — Ultrafine particles |
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Published online: 15-Dec-2015
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Year: 2016, Volume: 35, Issue: 1 |
Page From: 35, Page To: 43 |
doi:10.4149/gpb_2015031
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