Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
General Physiology and Biophysics Vol.32, No.1, p.33–45, 2013 |
||
Title: Suppression of membrane vesiculation as anticoagulant and anti-metastatic mechanism. Role of stability of narrow necks | ||
Author: Roman Štukelj, Vid Šuštar, Anita Mrvar-Brečko, Peter Veranič, Henry Hägerstrand, Veronika Kralj-Iglič, France Sevšek | ||
Abstract: Nanovesicles that are pinched off from biological membranes in the final stage of budding constitute a cell-cell communication system. Recent studies indicate that in vivo they are involved in blood clot formation and in cancer progression. The bud is connected to the mother membrane by a thin neck so it dwells close to the mother membrane. Using the electron microscopy we have observed in blood cells that adhesion between the membrane of the bud and of the mother cell in the vicinity of the neck took place and prevented the bud to pinch off from the mother vesicle. The same effect was observed in giant phospholipid vesicles (GPVs) due to attractive interaction between the bud and the mother vesicle mediated by the plasma protein beta-2-glycoprotein I. The stability of the neck is important for this process. By using Fourier method we analyzed thermal fluctuations of a GPV while a protrusion composed of beads connected by thin necks was spontaneously integrated into the mother GPV. Stepwise change of Fourier coefficients indicates an increased stability of necks which contributes to the retention of buds by the mother membrane and promotes anticoagulant and anti-metastatic mechanism by suppression of nanovesiculation. |
||
Keywords: Flickering — Microvesicles — Nanovesicles — Thrombosis — Cance | ||
Year: 2013, Volume: 32, Issue: 1 | Page From: 33, Page To: 45 | |
doi:10.4149/gpb_2013007 |
||
|
download file |
|