Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 General Physiology and Biophysics Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Endocrine Regulations Vol.46, No.1, p.13-20, 2012 |
||
Title: Differential sensitivity to nicotine among hypothalamic magnocellular neurons | ||
Author: J. D. Mikkelsen, J. Jacobsen, A. Kiss | ||
Abstract: Objectives. The magnocellular neurons in the hypothalamic paraventricular (PVN) and supraoptic nuclei (SON) either contain vasopressin or oxytocin. Even though both hormones are released after systemic administration of nicotine, the mechanism through which the two populations of neurons are activated is not known. This study was carried out in the rat to investigate the effect of increasing doses of nicotine on subsets of magnocellular neurons containing either oxytocin or vasopressin. Methods. The activated neurons were identified by means of Fos immunohistochemistry and the induction of Fos in magnocellular subdivisions was investigated by means of dual-immunohistochemistry. Results. While oxytocinergic neurons were sensitive to systemic administration of 0.5 mg/kg of nicotine, vasopressinergic neurons were not affected at doses up to 1 mg/kg. The vast majority (85%) of oxytocinergic neurons in the PVN was affected by nicotine, whilst only about half of the vasopressinergic neurons were stimulated, and only at maximal doses. Notably, the sensitivity of oxytocinergic neurons to nicotine was found to be different in the PVN and SON, because only about 55% of the SON oxytocinergic neurons co-stored Fos even after the highest dose of nicotine. Conclusion. These data show that magnocellular neurons are differentially regulated by nicotine and that their sensitivity is dependent on both their peptidergic phenotype and their location within the hypothalamus. |
||
Keywords: acetylcholine, vasopressin, oxytocin, Fos, stress, cell counting | ||
Year: 2012, Volume: 46, Issue: 1 | Page From: 13, Page To: 20 | |
doi:10.4149/endo_2012_013 |
||
|
![]() |
|