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Bratislava Medical Journal Vol.113, No.6, p.361–367, 2012 |
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Title: Prevalence of diabetes mellitus and glucose metabolism disorders in the first degree relatives of type 2 diabetic patients | ||
Author: A. Karaman, F. Bayram, K. Gundogan, M. Ozsan, H. Karaman, F. Kelestimur | ||
Abstract: Background and objectives: We designed this study to observe the DM prevalence, insulin resistance, beta cell reserve and the interaction of these parameters in the first degree relatives of Type 2 diabetic patients in Turkish population. Results: 12 (9.6 %) DM and 23 (18. 4 %) impaired glucose tolerance (IGT) cases of 125 subjects were diagnosed according to OGTT results. The mean BMI of diabetic subjects was significantly higher than of controls and subjects with normal glucose tolerance (p<0.05). When compared to the control group, the mean AUCinsulin levels were significantly lower in diabetic subjects (p<0.05). To observe the correlation between HOMAIR and KITT values, a statistically significant correlation was found (p<0.05, r: 0.222). There was a deficiency in the C-peptide response to glucagon stimulation in diabetic relatives (p<0.05, F: 4.59 One Way ANOVA). |
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Keywords: diabetes mellitus, first degree relatives of type 2 DM, insulin resistance. | ||
Year: 2012, Volume: 113, Issue: 6 | Page From: 361, Page To: 367 | |
doi:10.4149/BLL_2012_082 |
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