Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma 2024 Ahead of print 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.53, p.305-308, 2006 |
||
Title: Low frequency of the CHEK2*1100delC mutation among breast cancer probands from three regions of Poland | ||
Author: E., KWIATKOWSKA ; E., SKASKO ; A., NIWINSKA ; A., WOJCIECHOWSKA-LACKA ; J., RACHTAN ; L., MOLONG ; D., NOWAKOWSKA ; B., KONOPKA ; A., JANIEC-JANKOWSKA ; Z., PASZKO ; J., STEFFEN ; | ||
Abstract: The 1100delC germline mutation of the CHEK2 gene appears to contribute significantly to the overall breast cancer incidence
in some West and North European countries, but seems to be much less frequent among breast cancer patients from
other regions of Europe. In the present study we found, respectively, 3/487, 1/296 and 0/279 carriers of this mutation among
breast cancer patients from the East-Central, South-East and West-Central regions of Poland. Two carriers of the 1100delC
mutation were found among 120 patients with bilateral breast cancer, but only one had a previous family incidence of breast
cancer. We found no carriers among 182 patients with unilateral breast cancer with family history of this tumor and among
64 patients with breast cancer and a second primary tumor at an other site. We conclude that the 1100delC mutation of the
CHEK2 gene contributes little to the overall breast cancer burden in Poland, including familial cases of this malignancy.
Further studies are still needed to evaluate the contribution of this mutation to the development of bilateral breast tumors.
|
||
Keywords: breast cancer, CHEK2*1100delC mutation, population differences | ||
Year: 2006, Volume: 53, Issue: | Page From: 305, Page To: 308 | |
|
download file |
|