General Physiology and Biophysics Vol.26, p.168-172, 2007
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Title: QT interval prolongation and decreased heart rates after intravenous
bolus oxytocin injection in male and female conscious rabbits |
Author: M. Uzun, K. Yapar, E. Uzlu, M. Citil, H. M. Erdogan |
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Abstract: The aim of this study was to evaluate changes in heart rate (HR), QT and RR intervals and corrected QT (QTc) values in conscious male and female New Zealand rabbits which intravenously received oxytocin (OXT) at different dosages. Animals were divided into 6 equal groups: group I (n = 6 male, received 0.75 U OXT per animal); group II (n = 6 male, received 1.5 U OXT per animal); group III (n = 6 male, received 3 U OXT per animal); group IV (n = 6 female, received 0.75 U OXT per animal); group V (n = 6 female, received 1.5 U OXT per animal); group VI (n = 6 female, received 3 U OXT per animal). ECG recording were taken from all animals before injection and then at 2, 4, 6, 8, 10, 15 and 20 min of OXT administration. QT and RR intervals obtained at 2 min of OXT administration were significantly prolonged in all groups (p emale rabbits. In conclusion, OXT used in therapeutic dosages decreased heart rate and prolonged QT and QTc intervals. Although cardiovascular effect of OXT are of short duration, its use in patient with risk factors for malignant arrhythmias requires more attention.
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Keywords: Oxytocin — QT interval — Female and male rabbits |
Year: 2007, Volume: 26, Issue: |
Page From: 168, Page To: 172 |
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