Home General Physiology and Biophysics 2024 General Physiology and Biophysics Vol.43, No.1, p 57–71, 2024

Journal info


Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
Published in English,
6 times per year

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

General Physiology and Biophysics Vol.43, No.1, p 57–71, 2024

Title: Combination therapy of metformin and atorvastatin against benzopyrene-induced lung cancer via inflammatory signaling pathway
Author: Xuecong Ning, Shusen Zhang, Zhiguo Gao, Aimin Li

Abstract: The most prevalent cause of lung cancer is smoking tobacco, but exposure to second hand smoke, air pollution, and certain chemicals and substances at work can also raise the risk of disease. In this study, we scrutinized the chemoprotective effect of the metformin and atorvastatin combination against benzo[a]pyrene (BaP)-induced lung cancer in mice of Swiss albino. BaP (50 mg/kg) was used for induction of lung cancer and mice were treated with metformin, atorvastatin or their combination. Metformin + atorvastatin combination significantly (p < 0.001) improved the body weight, liver weight, suppressed the lung weight and tumor incidence and altered the levels of immunocompetent cells, polyamines, lung tumor markers, lung parameters and antioxidant parameters, respectively. Metformin + atorvastatin combination also suppressed cytokines levels, inflammatory parameters and caspase parameters. On the basis of the results, we can conclude that metformin + atorvastatin combination remarkably suppressed lung cancer via the inflammatory pathway.


Keywords: Metformin — Atorvastatin — Lung cancer — Polyamine — Inflammation
Published online: 17-Jan-2024
Year: 2024, Volume: 43, Issue: 1 Page From: 57, Page To: 71
doi:10.4149/gpb_2023030


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.