Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.66, No.3, p. 216 – 227, 2022 |
||
Title: A gene expression signature that correlates with CD8+T cell expansion in acute Epstein-Barr virus infection | ||
Author: Yijing Chen, Hanqing Wang, Xia Liu, Bing Luo | ||
Abstract: Acute infectious mononucleosis (AIM) is associated with Epstein-Barr virus (EBV) infection. We explored molecular mechanisms regarding the expression of CD8+T cells in convalescence stage (CONV). Differentially expressed genes (DEGs) were identified by analyzing GEO expression profiles. Subsequently, Gene Set Enrichment Analysis (GSEA), Protein-Protein Interactions (PPI) network, and gene-micro RNAs networks were used to identify hub genes and associated pathways. GSEA provided evidence that the top 3 gene sets in GSEA were all related to integrins. We identified ten hub genes in the PPI network and DGIdb was applied to predict potential targets that might reverse the expression of hub genes. Our study enhances a mechanistic understanding of the CD8+T cells expansion in acute EBV infection and provides potential treatment targets for further research. |
||
Keywords: acute infectious mononucleosis; bioinformatics; CD8+T cells; differentially expressed genes; EBV | ||
Published online: 27-Aug-2022 | ||
Year: 2022, Volume: 66, Issue: 3 | Page From: 216, Page To: 227 | |
doi:10.4149/av_2022_303 |
||
|
download file |
|