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Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.3, p.149-152, 2017
Bratislava Medical Journal 2017 Bratislava Medical Journal Vol.118, No.3, p.149-152, 2017
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Bratislava Medical Journal Vol.118, No.3, p.149-152, 2017 |
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| Title: Investigation of anticarcinogenic and antioxidant effects of -methylimidazole | ||
| Author: M. Norizadeh Tazehkand, O. Hajipour, F. Moridikia, A. Moridikia, E. Valipour, M. B. Yilmaz, M. Topaktas | ||
| Abstract: 4-methylimidazole is widely used in pharmaceuticals, photographic and agricultural chemicals. The substance is extensively found in many human and animals foods. In this research, anticancer effect of the 4-MEI was studded using MTT test using MCF-7 cell line. Effect of the 4-MEI on apoptosis or necrosis was analyzed by DNA fragmentation assay using Swiss Albino rats as a model organism. Antioxidant effect of the substance was investigated by assaying protective effect of the substance on circular plasmid DNA against H2O2 as an oxidative agent. 4-MEI showed inhibitory effect on proliferation of MCF-7 cell line by all concentrations and the decrement was significant and concentration dependent. Result of DNA fragmentation assay showed 4-MEI concentrations dependent of smear formation showing necrotic effects of the 4-MEI on mouse cells. Also, the 4-MEI showed a good antioxidant activity and protective effect against H2O2. CONCLUSION: The result of this study showed that 4MEI has significant antioxidant and anti-cancer effect. Also, according to the result, 4-MEI has necrotic effects on mouse cells (Fig. 3, Ref. 21). |
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| Keywords: 4-MEI, MCF-7, fragmentation, antioxidant, anticancer | ||
| Published online: 14-Mar-2017 | ||
| Year: 2017, Volume: 118, Issue: 3 | Page From: 149, Page To: 152 | |
| doi:10.4149/BLL_2017_029 |
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