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Bratislava Medical Journal Vol.118, No.2, p.107-111, 2017 |
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Title: Flow cytometric examination of apoptotic effect on brain tissue in postnatal period created by intrauterine oxcarbazepine and gabapentin exposure | ||
Author: Z. Erisgin, Y. Tekelioglu | ||
Abstract: OBJECTIVE: For epileptics, pregnancy contains the balance between no seizure period and antiepileptic use having the least teratogenicity risk. The purpose is to analyse with flow cytometry the apoptotic effects on postnatal brain tissue caused by prenatal use of second generation antiepileptics oxcarbazepine (OXC) and gabapentin (GBP) having different effect mechanisms. Considering time effect in three treatment groups, while difference was not significant for PSS and GBP groups (p = 0.847 and p = 0.934), apoptosis rate was significantly high for OXC on the 6th–15th days compared to the 1st–5th days (p < 0.001). |
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Keywords: apoptosis, flow cytometry, gabapentin, oxcarbazepine, pregnancy | ||
Published online: 16-Feb-2017 | ||
Year: 2017, Volume: 118, Issue: 2 | Page From: 107, Page To: 111 | |
doi:10.4149/BLL_2017_022 |
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