Home General Physiology and Biophysics 2014 General Physiology and Biophysics Vol.33, No.3, p.335–344, 2014

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Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.33, No.3, p.335–344, 2014

Title: Ouabain modulation of snail Br neuron bursting activity after the exposure to 10 mT static magnetic field revealed by Higuchi fractal dimension
Author: Srdjan Kesić, Ljiljana Nikolić, Aleksandar G. Savić, Branka Petković, Sladjana Z. Spasić

Abstract: Aim of this study was to investigate the application of normalized mean of the empirical Higuchi fractal dimension (FD) distributions, as a new approach to analyze the spontaneous bioelectrical activity of garden snail (Helix pomatia) Br neuron. The effect of ouabain on modulation of Br neuron bursting activity before and after the exposure to 10 mT static magnetic field (SMF) was observed by analyzing the following parameters: action potential (AP), interspike interval (ISI) and interbursting interval (IBI) components. Normalized mean of the empirical FD distributions were formed for the following experimental conditions: Control 1, Ouabain 1, Control 2, SMF 2, ASMF 2, Control 3, SMF 3 and Ouabain ASMF 3. Our main results have shown that ouabain without SMF induced increase in participation of AP and a decrease in participation of IBI components compared to the first control condition. However, in the presence of 10 mT SMF, ouabain-induced changes of measured parameters of Br neuron activity were less pronounced compared to the third control condition. We have shown that normalized mean of the empirical FD distributions is a useful method for detecting the changes in AP, ISI, and IBI components of complex bursting activity in altered physiological states.

Keywords: Higuchi fractal dimension — Bursting activity — Ouabain — Na/Kpump — Static magnetic field
Published online: 12-Jun-2014
Year: 2014, Volume: 33, Issue: 3 Page From: 335, Page To: 344
doi:10.4149/gpb_2014010


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