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Bratislava Medical Journal Vol.115, No.6, p.330-333, 2014 |
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Title: Changes of serum angiogenic biomarkers and their correlations with serum leptin concentration | ||
Author: Z. Tahergorabi, M. Khazaei | ||
Abstract: Aim: Obesity is considered as a major health problem. Angiogenic vessels by providing oxygen, nutrients and growth factors trigger growth and survival signals in adipocytes. We aimed to investigate the effect of high-fat diet (HFD) on serum angiogenic biomarkers including vascular endothelial growth factor (VEGF), soluble VEGF receptor 1 (sVEGFR1), nitric oxide (NO) concentrations and their correlations with serum leptin level in obese and control groups. There was a strong positive correlation between serum leptin and NO levels (r=0.78), however, a weak correlation was found between serum leptin and VEGF and VEGFR-1 concentrations.
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Keywords: obesity, angiogenesis, leptin, angiogenic factors. | ||
Year: 2014, Volume: 115, Issue: 6 | Page From: 330, Page To: 333 | |
doi:10.4149/BLL_2014_065 |
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